Signaling Pathways Involved in Mammalian Sex Determination and Gonad Development
نویسندگان
چکیده
منابع مشابه
Signaling Pathways Involved in Mammalian Sex Determination and Gonad Development.
The development of any organ system requires a complex interplay of cellular signals to initiate the differentiation and development of the heterogeneous cell and tissue types required to carry out the organs' functions. In this way, an extracellular stimulus is transmitted to an intracellular target through an array of interacting protein intermediaries, ultimately enabling the target cell to ...
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In mammals, sex is determined by the presence or absence of a single gene on the Y chromosome, Sry. Sry, a member of the high mobility group family of transcription factors, is required to initiate male-specific pathways and repress female-specific pathways. Expression of Sry in the gonad, beginning at 10.5 days postcoitum, leads to the differentiation of the somatic supporting cell precursors ...
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ژورنال
عنوان ژورنال: Sexual Development
سال: 2016
ISSN: 1661-5425,1661-5433
DOI: 10.1159/000444065